The Home Run trophy in Spider-Man 2 is a Bronze trophy that requires you to Round the bases at the Big Apple Ballers Stadium.
But where do you find the Big Apple Ballers Stadium? You can find the stadium in the Downtown Brooklyn region of the city, which is way down on the bottom right of the map. You can see this location in the screenshots below.
And how do you round the bases? Being Scottish, I have no clue about Baseball. But I have seen baseball being played on TV and in films so I figured that you just have to run around the bases (white squares) on the stadium playing field.
And run around the bases I did until the trophy popped. Take a look at the video below to see where to go and how to run around the bases.